Longevity Questions

Konstantin, [06.05.2025 19:24]
ChatGPT 4.5
Question: "How to increase life expectancy to 200 years"
20 level 1 questions to this question:
1. What fundamental mechanisms of aging must be completely suppressed or significantly slowed down to reach the age of 200 years?
2. What role do protein damage and proteostasis disorders play in aging, and what methods can effectively maintain the quality of the proteome for two centuries?
3. How can we prevent the accumulation and spread of mitochondrial mutations and dysfunctions that lead to age-related tissue degeneration?
4. How can we completely control epigenetic changes that lead to the loss of cellular identity and functionality over long periods of life?
5. What mechanisms can ensure full regeneration of organs and tissues in an adult for 200 years?
6. Is it possible to maintain stem cells in a young, functional state for two hundred years, and what mechanisms of regulation of their pool should be studied and used?
7. What methods allow us to effectively manage systemic inflammation and immune aging over long periods of time?
8. What cellular and molecular mechanisms can help maintain the health of blood vessels and the cardiovascular system for 200 years?
9. What processes of regulation of neural plasticity and preservation of cognitive functions can work effectively for two centuries?
10. How can we stabilize the extracellular matrix and prevent its degradation, which is an important component of tissue aging?
11. What molecular mechanisms can ensure constant stability and accuracy of DNA repair for 200 years?
12. How can we effectively slow down or completely stop the accumulation of cellular senescent phenotypes in the body?
13. What biological mechanisms or genetic modifications can significantly slow the rate of endocrine system aging, maintaining hormonal balance for centuries?
14. Is it possible to maintain or even improve the ability of cells to autophagy and cleanse themselves of defective structures for two hundred years, and if so, by what methods?
15. What is the role of the microbiome in long-term health maintenance, and what methods of regulating its composition and activity can ensure the viability of the body for 200 years?
16. How can we ensure sustainable energy efficiency and metabolic balance of body cells over an extremely long period?
17. What genetic or epigenetic modifications can be made to achieve a significant extension of the maximum lifespan of a person?
18. How can we ensure full coordination and integration of all levels of body regulation (from molecular to systemic) to maintain long-term coherence and functionality?
19. What level of biological control and intervention is required to prevent age-related cancer development over 200 years?
20. What new technologies and computational approaches are needed to model and predict the body's vulnerabilities, with the goal of personalized life extension to 200 years?
20 Level 2 questions for the first question from the list ("What fundamental mechanisms of aging must be completely suppressed or significantly slowed down to reach the age of 200 years?"):
1. What molecular processes are the basis of aging, and which of them have the greatest impact on lifespan?
2. How are key mechanisms of aging, such as the accumulation of DNA damage, proteostasis, mitochondrial dysfunction, epigenetic changes and cellular senescence, related?
3. What is the role of intracellular and intercellular signaling in accelerating the aging of the organism?
4. What genetic factors most significantly affect the rate of aging, and how can they be identified?
5. Which aging mechanisms primarily limit maximum lifespan in long-lived species?