Longevity Questions

Konstantin, [06.05.2025 19:24]
6. Are there fundamental mechanisms of aging that are common to all multicellular organisms, and what are they?
7. How do disturbances in intercellular communication contribute to systemic aging of the body?
8. Which of the fundamental mechanisms of aging can be suppressed by genetic or epigenetic modifications?
9. What is the role of the immune system in the general scenario of aging, and which of its aspects need to be suppressed or controlled?
10. Which fundamental mechanisms of aging are associated with disturbances in cellular metabolism and energy balance?
11. Does the accumulation of somatic mutations affect the aging of the body so significantly that their suppression will become a prerequisite for reaching the age of 200 years?
12. Which of the known molecular and cellular mechanisms of aging are irreversible, and which can be effectively reversed?
13. How is chronic inflammation (“inflammaging”) related to other fundamental mechanisms of aging?
14. What processes in the epigenome determine the rate of biological aging, and how can we effectively intervene in their regulation?
15. How exactly does a decrease in the ability of cells to autophagy accelerate aging, and what mechanisms of autophagy control must be activated?
16. How are failures in the protein-synthesizing and protein-degrading systems of cells fundamental causes of aging?
17. Are there systemic mechanisms of aging that do not depend on intracellular processes, such as degradation of the extracellular matrix?
18. How significantly does the accumulation of senescent cells affect the aging process and should such cells be completely eliminated?
19. What fundamental mechanisms of aging are first triggered in the body, and is it possible to intervene at this stage to slow down subsequent aging?
20. What level of reduction in the intensity of these aging mechanisms is necessary to increase lifespan to 200 years, and how can it be objectively measured?
20 Level 3 questions for the first Level 2 question (“What specific molecular processes underlie aging, and which of them have the greatest impact on lifespan?”):
1. What specific biochemical reactions cause irreversible changes that lead to cellular aging?
2. Which molecules in the cell are most vulnerable to age-related damage?
3. How exactly is the accumulation of damaged proteins related to the molecular processes of aging?
4. Which DNA repair pathways are most critical for slowing aging and why?
5. How does mitochondrial dysfunction cause cascade effects that lead to accelerated aging?
6. Which specific types of reactive oxygen species (ROS) have the greatest impact on the aging process?
7. What are the molecular mechanisms of age-related loss of cellular identity?
8. How do molecular changes associated with telomere shortening influence tissue aging?
9. What are the precise mechanisms of epigenetic changes that trigger cellular aging?
10. Which metabolites most significantly accelerate the aging process?
11. Which molecular markers of aging most accurately reflect the biological age of a cell or organism?
12. What specific molecular changes lead to a decrease in the regenerative potential of cells?
13. How does the loss of proteostasis at the molecular level initiate systemic aging?
14. How do molecular mechanisms of the immune response change with age, and why does this affect aging?
15. What are the molecular processes of aging of the extracellular matrix and how do they affect the body?
16. Which signaling molecules most critically regulate the processes of cellular aging?
17. How exactly does imbalance in calcium and other ion regulation at the molecular level accelerate aging?
18. What specific changes in lipid metabolism are associated with aging processes?
19. By what molecular pathways does chronic inflammation (inflammaging) accelerate aging?
20. What molecular processes associated with impaired energy metabolism most significantly reduce life expectancy?