Longevity Questions

Konstantin, [06.05.2025 19:24]
20 level 4 questions for the first question of the third level ("What specific biochemical reactions cause irreversible changes that lead to cellular aging?")
1. What specific enzymatic reactions in the cell are responsible for the accumulation of damage that leads to aging?
2. What types of oxidative stress reactions most often lead to irreversible damage to cellular structures?
3. What are the exact mechanisms of the protein glycation reaction and their relationship with cellular aging?
4. What specific molecular events are triggered when mitochondrial DNA is damaged and what reactions are involved in their amplification?
5. How exactly do biochemical reactions associated with lipid peroxidation lead to the degradation of cell membranes?
6. What specific reactions lead to the formation of protein aggregates and how is this related to cellular aging?
7. What molecular mechanisms underlie irreversible epigenetic changes that accelerate aging?
8. What reactions lead to the loss of lysosome function during aging?
9. What molecular reactions are triggered by telomere shortening that lead to cellular senescence?
10. What specific biochemical reactions trigger the apoptotic or senescent cascade of aging cells?
11. What reactions in glucose and other sugar metabolism trigger irreversible changes that contribute to aging?
12. What chemical reactions are associated with the accumulation of damage in the protein-synthesizing system of the cell?
13. What specific reactions are involved in the disruption of cellular regulation of ion balance that affects aging?
14. What are the biochemical mechanisms of the reaction of irreversible binding of metals (e.g. iron and copper) that accelerate aging?
15. What reactions lead to the formation of irreversible DNA adducts that cause mutations and aging of cells?
16. What enzymatic reactions are involved in the disruption of DNA repair processes with age?
17. Which specific reactions of extracellular matrix degradation most actively influence cellular and tissue aging?
18. Which specific reactions produce free radicals that directly damage cellular components?
19. Which biochemical reactions associated with disruption of calcium signaling lead to age-related cellular damage?
20. Which reactions are associated with disruption of autophagy regulation at the biochemical level, and how does this lead to the accumulation of damage?
20 Level 5 questions for the first question of Level 4 (“Which specific enzymatic reactions in the cell are responsible for the accumulation of damage leading to aging?”):
1. Which specific enzymes are involved in the generation of reactive oxygen species (ROS) that cause damage with age?
2. Which enzymatic reactions lead to the accumulation of oxidized proteins in cells?
3. How do enzymatic defects affect the disruption of repair of damaged proteins?
4. Which enzymes are responsible for maintaining telomeres, and what reactions lead to their suppression with age?
5. Which enzymes and reactions are involved in pathological glycation of intracellular proteins?
6. Which enzymes cause lipid peroxidation, and why does their activity increase with age?
7. What specific enzymatic reactions disrupt epigenetic regulation with age?
8. Which enzymes are responsible for the degradation and disruption of the structure of the extracellular matrix?
9. What effect do age-related changes in the activity of DNA repair enzymes have on the accumulation of genomic damage?
10. Which enzymatic processes lead to the formation of irreversible protein aggregates in cells?
11. Which enzymes are involved in the activation of cellular apoptosis during aging?
12. How does proteasome enzymatic activity change with age and how does this affect cell aging?
13. Which enzymes are involved in the age-related weakening of the cell's autophagic mechanism?
14. Which enzymes regulate the metabolism of calcium and other ions, the disruption of which contributes to aging?
15. Which enzymatic reactions are associated with changes in energy metabolism and deterioration of mitochondrial function?
16. Which enzymes specifically trigger chronic inflammation at the cellular level during aging?