Konstantin, [06.05.2025 19:26]
I. Structural recalculation: where is the "core" of the problem?
Of the entire pyramid:
• Levels 1–3 are the semantic framework covering key areas.
→ ~400–500 unique questions.
• Levels 4–6 are the core of the mechanics, where the maximum of biological unsolved problems lie.
→ approximately ~50,000 – 200,000 truly meaningfully distinguishable questions.
• Levels 7–9 are primarily technological detailing (methods, parameters, domains, proteins, protocols).
→ here no more than 0.01% of questions require a fundamental answer — the rest depend on technical progress.
Conclusion:
🔸 The fundamental complexity of the problem is no more than 100,000–300,000 questions grouped into ~1,000–3,000 semantic clusters.
🔸 Solving at least 500 of them (key clusters) will provide a breakthrough to controlled slowing of aging.
🔸 The rest are the path to stabilizing the body's condition for 200 years.
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🧠 II. What is considered a fundamental scientific question?
A fundamental question in this area:
• Cannot be reduced to an existing scheme (cannot be reduced to a known biomarker, pathway, or method).
• Changes the level of understanding of the aging mechanism or intervention.
• Provides a cascade effect of closing lower tasks.
• Can be posed as a formalized hypothesis (ideally, tested by experiment or simulation).
Examples (in terms suitable for design and verification):
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🔑 III. Examples of the three primary fundamental questions
1. Where does the primary phase shift occur that leads to the aging cascade?
• Is there a universal node (e.g. in the disruption of proteostasis, epigenetics, matrix) where the regulation loses stability?
• Can this be mathematically described as a bifurcation in a dynamic system?
Value: Identifying the primary node will allow us to build a reversible model of the initiation of aging.
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2. How to reproduce and maintain sustainable self-regeneration of mature tissues without oncogenic risk?
• What limits the regenerative program in the mature organism - signals, epigenetics, immune control?
• Which cycles are suppressed - and which can be restarted without transition to proliferative instability?
Value: This is the transition from “repair” to a stable equilibrium of youth.
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3. How to ensure the coherence of molecular processes (reparation, synthesis, expression) for 200 years?
• What are the limits of the accuracy of enzymatic systems, and how do they degrade?
• Is it possible to introduce corrective mechanisms (enzyme substitution, molecular control, local interventions)?
Value: This is the foundation of safety and longevity - without coherence, no extension is possible.
