Longevity Questions

Perpetual Prompt ♾️, [08.05.2025 14:46]
425.Are there socio-psychological mechanisms that allow for the development of a global consensus regarding death as a technical failure without causing deep socio-polarization?

426.What is the recall and precision value of a large language agent in an automated literature review on the biology of aging compared to the work of a subject-matter expert human?

427.Is it possible to integrate online-omics databases and patent repositories into a multi-agent AI system that will autonomously generate formalizable and testable hypotheses about life extension?

428.What metrics (retrospective hit-rate, in silico docking, probabilistic calibration) allow for objective validation of hypotheses generated by an AI agent without human intervention?

429.Could a fully autonomous AI-driven laboratory platform complete the hypothesis→experiment→analysis cycle faster and cheaper than a traditional scientific consortium in gerontology?

430.What is the minimum amount of connectome and synaptic weight data required for a digital model of the human brain to reproduce the full behavioral repertoire?

431.Would additional data on the dynamics of glial networks and neuromodulatory currents be needed to reproduce subjective consciousness in a digital model?

432.What experimental protocols (e.g., hidden information or noise tolerance tests) can empirically reveal the presence of phenomenal consciousness in an artificial neural system?

433.Are there theoretical or physical limitations that prevent the continuous transfer of human personal identity from a biological to a digital substrate without losing the sense of "I"?

434.What is the minimum cortical module in mammals that exhibits integrated information Φ>0.5, sufficient for the emergence of a conscious state?

435.To what extent does the index of integrated information Φ decrease and subjective perception disappear with selective suppression of γ-rhythms in the cerebral cortex?

436.Is it possible to restore the lost Φ index and return the conscious state after severe brain injury using optogenetic phasic stimulation?

437.Is a reversible major reduction of consciousness possible by controlled reduction of integrated informationΦ for long-term space flights and extreme life extension?

438.What is the minimum energy supply of the cerebral cortex (in μmol ATP g⁻¹ min⁻¹) necessary to maintain integrated informationΦ above the threshold of conscious perception in 100-year-old people?

439.To what extent does the accumulation of senescent astrocytes reduce the coherence of γ-oscillations that form the neural substrate of the global workspace of consciousness, and can this be reversibly corrected by senolytic therapy?

440.How does age-dependent decrease in the level of the neurotrophin BDNF affect the capacity of the cortico-subcortical loops that provide the subjective sense of "I"?

441. How does the rate of epigenetic aging (according to the DNA methylome clock) of prefrontal cortex neurons correlate with the metacognitive accuracy of self-reflection in people of different age groups?

442. Could local partial reprogramming of neurons (OSK factors) increase the integration capacity of their network without erasing long-term memory and personal identity?

443. How does chronic systemic inflammation (inflamm-aging) shift the threshold for switching on the default-modenetwork associated with autobiographical consciousness?

444. Was there a quantitative relationship between telomere shortening in hippocampal neural stem cells and age-related distortion of subjective time perception?

445. What types of mitochondrial mutations in cortical neurons most strongly disrupt the accuracy of neural coding necessary for stable phenomenal awareness?

Perpetual Prompt ♾️, [08.05.2025 14:46]
446. To what extent can the general metabolic rate of the body be reduced (for example, by long-term therapy with metformin or SGLT2 inhibitors) so that the integrated information indicator Φ—a scalar value in bits from Tonnoni's Integrated Information Theory that quantitatively describes the degree of causal interdependence of the neural network and serves as an operational indicator of continuous waking consciousness—does not fall below the critical threshold of disappearance of subjective perception?

447. How does age-related degradation of the extracellular matrix of the brain affect the structural integrity of the salience network and the ability to maintain stable attentive focus?

448. Can long-term maintenance of stable circadian rhythms (through melatonin, controlled light therapy, etc.) simultaneously slow down epigenetic aging of the cerebral cortex and restrain the age-related decline in integrated information Φ, where Φ is interpreted as a numerical (bit) measure of the integration of causal information in the brain network and thus reflects the “capacity” of the system to maintain holistic consciousness?

449. Does pharmacological suppression of chronic microglial activation with selective CSF1R inhibitors restore the integrated information index Φ, a quantitative metric of IIT calculated using functional connectomics and reflecting the level of global integration of signals, to values ​​characteristic of young age, and is this accompanied by a subjective improvement in lucidity in elderly patients?

450. How does therapeutic enhancement of neuroplasticity (through modulation of NMDA receptors or the use of psychedelics) affect the rate of aging of neural networks and the long-term stability of self-awareness?