Longevity Questions

Perpetual Prompt ♾️, [08.05.2025 21:24]
691. What molecular signaling pathways are activated in naked mole rats under social hierarchy conditions and how do they relate to aging pathways (IGF-1, mTOR, AMPK)?
692. What epigenetic profiles are characteristic of dominant (royal) individuals in social animals and can they be artificially reproduced in humans?
693. Can people who occupy high social positions in stable groups show slower epigenetic aging?
694. Can molecular markers of social isolation (for example, in lonely people) predict accelerated aging?
695. How does maintaining a complex social structure in naked mole rats affect their immune system and tissue repair?
696. Are there common transcriptomic patterns between longevity in eusocial insects and naked mole rats?
697. Which neuropeptides or hormones (e.g., oxytocin, vasopressin) correlate with longevity in hypersocial species?
698. Can increased social cooperation in human groups reduce biomarkers of inflammation (CRP, IL-6) and aging?
699. How does stress caused by disruption of social hierarchy affect telomere length in mammals?
700. Is it possible to extend the lifespan of a model organism (e.g., a mouse) by simulating a social structure similar to a colony of naked mole rats?

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701. What metabolic changes occur in naked mole rat “queens” compared to workers?
702. How does task sharing (e.g. in ants or bees) reduce metabolic load, and can this be applied in principle to humans?
703. What microbiome features are characteristic of highly social species, and do they affect aging?
704. How does group behavior (e.g., sharing food, sleep synchrony) affect circadian rhythms and lifespan?
705. Can optimization of social rituals (support, shared labor, status) in humans cause a geroprotective effect?
706. Which genes are differentially expressed between mothers and subordinates in naked mole rats, and can they be edited in humans?
707. Is there a “social longevity” phenotype in humans — long-lived individuals with high levels of social activity and involvement?
708. What psychosocial practices (meditation, rituals, hierarchies) correlate with a decrease in the speed of the epigenetic clock?
709. Is it possible to study the effect of social hormones on the rate of neuronal aging using a brain organoid model?
710. How does a change in group status (increase/decrease) affect the biochemistry of aging in primates?

711. How significant is the contribution of social stability in a population to the molecular slowing of aging in humans in the Blue Zones?
712. What are the long-term consequences of chronic social deprivation in childhood for aging?
713. Can senolytics be more effective in conditions of social support or cognitive stimulation?
714. What behavioral patterns in a naked mole rat colony serve as predictors of the future lifespan of an individual?
715. Is it possible to transplant epigenetic profiles of “alpha individuals” (e.g., ant queens) into human induced stem cells?
716. Are there differences in the expression of FOXO3, SIRT1, and TERT between social castes in eusocial animals?
717. How does the level of interpersonal trust affect physiological stress and biomarkers of aging in humans?
718. Is it possible to create an experimental digital colony of people with a controlled social hierarchy and measure the effect on biomarkers of aging?
719. What psychosocial models explain the correlation between social inclusion and median survival?
720. Can simulating the social structure of mole rats in a VR/AR environment induce physiological changes in humans?