Longevity Questions

Perpetual Prompt ♾️, [09.05.2025 00:17]
1081.What is the minimum daily dose of pegvisomant (mg/kg) that will reduce IGF-1 levels in 40-50 year old men below the 25th percentile without losing ≥3% of muscle mass in 12 weeks?
1082.By what %, according to DXA scanning, does L1-L4 bone mineral density decrease in 55-60 year old women after a 1-year reduction in IGF-1 by 30% from the median level?
1083.How does maximum grip strength (kg) change in 65-70 year olds after 6 months of treatment with somatostatin analogs that reduced IGF-1 by 15%?
1084. What level of IGF-1 (ng/ml) is associated with the lowest incidence of colorectal adenomas in men aged 50–55 years with colon screening every three years?
1085. By what percentage does the HOMA-IR index change after a three-month low-protein diet (0.6 g protein/kg) in people aged 35–45 years if IGF-1 decreases by at least 20%?
1086. What is the threshold level of serum IGF-1 at which the rate of epigenetic aging according to the Horvath DNAmAge method exceeds the calendar age by <5% in women aged 45–50 years?
1087. How many milligrams of metformin per day are required to maintain IGF-1 in the range of 100-120 ng/ml in patients aged 40-60 years without diabetes mellitus?
1088. How much (in µm) are leukocyte telomeres shortened per year in patients aged 60-65 years with chronic IGF-1 <70 ng/ml compared to controls IGF-1 ≈140 ng/ml?
1089. Which SNP in the IGF1R gene is most reliably associated with an increased risk of insulin resistance with IGF-1>180 ng/ml in women aged 30-40 years?
1090. By what % does the volume of gray matter in the prefrontal cortex decrease according to MRI data after two years of taking GH secretagogues, which increased IGF-1 by 25% in men aged 60-65?
1091. How does the incidence of hip fractures (per 1000 people/year) change in women aged 70-75 with IGF-1 <80 ng/ml compared to the range of 120-140 ng/ml?
1092. What is the median time to achieve MOCO (menopause-onset vasomotor symptom offset) in women aged 45-50 with IGF-1 levels in the lower quartile of the age norm?
1093. By what percentage (from baseline) does the glomerular filtration rate decrease in patients aged 55–65 years after two years of therapy that reduces IGF‑1 by 35%?
1094. What is the VO₂ max (mlO₂/kg/min) achieved by men aged 50–55 years who practice 16:8 intermittent fasting and maintain IGF‑1 in the range of 90–110 ng/ml?
1095. How many days is it necessary to maintain serum IGF‑1 <85 ng/ml to observe a 10-fold increase in FOXO3A gene expression in peripheral blood?
1096. What is the frequency of hypoglycemic episodes (per 100 people/year) in veteran athletes aged 45–55 years taking IGF-1R inhibitors that reduce IGF-1 by 20%?
1097. By what amount (in mm) does the average carotid intima-media thickness decrease in 60–65 year olds after six months of treatment that increases IGF-1 by 15%?
1098. What level of IGFBP-3 is needed to keep the IGF-1/IGFBP-3 ratio ≤0.25 with serum IGF-1=130 ng/ml in women aged 35–45 years?
1099.What is the percentage of Ki-67 expressing cells in prostate biopsies from men aged 55–65 years with long-term (≥12 months) IGF-1>200 ng/ml?
1100.How many hours after taking orlistat (120 mg) is a statistically significant decrease in IGF-1 (p<0.05) observed relative to baseline values ​​in obese patients?
1101.What is the increase in Achilles tendon length (in %) recorded by ultrasound in athletes aged 40–50 years after six months of rhIGF-1 injections (40 µg/kg twice a week)?
1102. How much does the hearing threshold at 4 kHz deteriorate over 10 years in men aged 50-60 with IGF-1 <90 ng/ml compared to IGF-1 ≈150 ng/ml?
1103. What is the level of β-amyloid (pg/ml) in the cerebrospinal fluid in women aged 65-70 with IGF-1 in the upper quartile (>180 ng/ml) versus the lower quartile (<90 ng/ml)?
1104. How many additional milligrams of calcium per day are required to compensate for a 5% decrease in IGF-1 in women aged 60+ without deterioration of the T-score?
1105.What is the change in capillary density (number/mm²) in the vastus lateralis muscle after three months of a keto diet with IGF-1 <80 ng/ml in men aged 35–45?
1106.To what extent does the frequency of somatic mutations in epidermal cells increase (in petabases) in people aged 70–75 after three years of IGF-1 levels >190 ng/ml?

Perpetual Prompt ♾️, [09.05.2025 00:17]
1107.How does mean arterial pressure (mmHg) change in women aged 45–55 after six months of midazolam therapy, leading to a 10% decrease in IGF-1?
1108. How many person-years of follow-up are needed to detect a 20% reduction in all-cause mortality when maintaining IGF-1 in the range of 100-120 ng/ml in a population aged 40-70 years with α=0.05 and β=0.2?
1109. What is the area under the curve (AUC) of serum insulin over a 2-hour OGTT in 30-35 year olds with IGF-1<85 ng/ml versus IGF-1>150 ng/ml?
1110. By what percentage does visceral fat content decrease, as determined by MRI, in 50-55 year old men after a year of moderate aerobic exercise maintaining IGF-1 within the range of 110-130 ng/ml?